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. 2003 Nov 13;5(23):4249-51.
doi: 10.1021/ol030104p.

Asymmetric synthesis of 4,4-disubstituted-2-imidazoli-dinones: potent NK1 antagonists

Gregory A Reichard  1 , Carmine Stengone, Sunil Paliwal, Ingrid Mergelsberg, Sapna Majmundar, Cheng Wang, Robert Tiberi, Andrew T McPhail, John J Piwinski, Neng-Yang Shih
Affiliations

Asymmetric synthesis of 4,4-disubstituted-2-imidazoli-dinones: potent NK1 antagonists

Gregory A Reichard et al. Org Lett. .

Abstract

[structure: see text] A highly efficient and practical synthesis of 4,4-Disubstituted-2-Imidazolidinones utilizing a "self-reproduction of the center of chirality" strategy is described.

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