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. 2003 Nov 13;5(23):4485-8.
doi: 10.1021/ol0357999.

Assembling polycyclic bisguanidine motifs resembling batzelladine alkaloids by double tethered Biginelli condensations

Frederick Cohen  1 , Shawn K Collins, Larry E Overman
Affiliations

Assembling polycyclic bisguanidine motifs resembling batzelladine alkaloids by double tethered Biginelli condensations

Frederick Cohen et al. Org Lett. .

Abstract

[reaction: see text] Double tethered Biginelli condensations furnish linked polycyclic bisguanidines or bisureas. Alteration of the bis-beta-ketoester component allows bispolycyclic guanidine motifs to be constructed that resemble natural batzelladine alkaloids or have novel linkages.

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