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. 1977 Nov 10;39(2):221-4.
doi: 10.1007/BF00287015.

Grandmaternal age at birth of parents of children with trisomy 21

Z Papp, E Váradi, Z Szabó

Grandmaternal age at birth of parents of children with trisomy 21

Z Papp et al. Hum Genet. .

Abstract

The authors investigated the age of the parents and grandmothers of 262 children with simple trisomy 21. In cases in which the mother was under 30, the mean grandmaternal age was higher than that of the controls. This might mean that some of these cases, being the children of old mothers, began their lives as trisomic zygotes. The authors assume that not only maternal but also paternal mosaicism might be significant. They evaluate their results in light of genetic counseling and in consideration of practical conclusions that can be used in prenatal genetic diagnosis.

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References

    1. Am J Hum Genet. 1971 Nov;23(6):592-601 - PubMed
    1. Lancet. 1971 Mar 13;1(7698):549-50 - PubMed
    1. J Ment Defic Res. 1970 Dec;14(4):342-6 - PubMed
    1. J Genet Hum. 1964 Dec;13:315-36 - PubMed
    1. Hum Hered. 1977;27(5):305-9 - PubMed