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. 1992 Nov;14(3):207-11.
doi: 10.1007/BF00172596.

MR imaging of experimental meningeal melanomatosis in nude rats

J Martos  1 , D Petersen, U Klose, H Requardt, R Buchholz, P Ohneseit, M Schabet, K Voigt
Affiliations

MR imaging of experimental meningeal melanomatosis in nude rats

J Martos et al. J Neurooncol. 1992 Nov.

Abstract

MR imaging of the rat brain has become an increasingly frequently used method in experimental neuroradiology. On a generally available 1.5 T whole body tomograph, supplemented with an individually made small coil and a special SE sequence we obtained fairly fine images of the structures of the rat brain. With gadolinium-DTPA, we were able to visualize posterior fossa and cervical leptomeningeal growth of intrathecally injected B16 melanoma in nude rats. Using MRI to follow experimental leptomeningeal metastasis, may provide a new means for diagnostic evaluation and preclinical testing of treatment modalities.

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