Fatal hydrops fetalis caused by anti-D in a mother with partial D
- PMID: 14607035
- DOI: 10.1016/s0029-7844(03)00709-9
Fatal hydrops fetalis caused by anti-D in a mother with partial D
Abstract
Background: Rare cases of hemolytic disease of the newborn occur in women with genetic variants of the D antigen. A partial D variant might be suspected when typing for the D antigen shows weaker-than-normal reactions (weak D). Historically, patients with a weak D phenotype have not been considered candidates for Rh immune globulin prophylaxis.
Case: A gravida 2, para 1 woman with A-positive blood type, delivered an infant who died from severe hemolytic disease of the newborn 6 days after birth. Anti-D, undetectable at the first prenatal visit, was identified (titer 1:64) at delivery. The mother's red cells were partial D(VI) phenotype.
Conclusion: Although severe hemolytic disease in patients with partial D is rare, this neonatal death illustrates the need for a change in management of women with weak D.
Comment in
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Fatal hydrops fetalis caused by anti-D in a mother with partial D.Obstet Gynecol. 2004 Jul;104(1):193-4; author reply 194. doi: 10.1097/01.AOG.0000130983.59168.be. Obstet Gynecol. 2004. PMID: 15229025 No abstract available.
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Fatal hydrops fetalis caused by anti-D in a mother with partial D.Obstet Gynecol. 2004 Jul;104(1):194-5; author reply 195. doi: 10.1097/01.AOG.0000130984.72587.c4. Obstet Gynecol. 2004. PMID: 15229027 No abstract available.
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