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Comparative Study
. 2003 Nov 25;201(2):195-201.
doi: 10.1016/s0304-3835(03)00443-9.

BRPK, a novel protein kinase showing increased expression in mouse cancer cell lines with higher metastatic potential

Akinori Nakajima  1 , Ken Kataoka, Mei Hong, Masakiyo Sakaguchi, Nam-ho Huh
Affiliations
Comparative Study

BRPK, a novel protein kinase showing increased expression in mouse cancer cell lines with higher metastatic potential

Akinori Nakajima et al. Cancer Lett. .

Abstract

A novel protein kinase named BRPK was isolated and partially characterized. BRPK was expressed at a higher level in three carcinoma cell lines with higher metastatic potential. Mouse and human BRPK cDNAs are well conserved and encode 580 and 581 amino acids, respectively. BRPK has a serine/threonine-type protein kinase domain, and the recombinant proteins of BRPK were capable of autophosphorylation. The results of a comparative sequence analysis indicated a possible link of BRPK to BRAP2. BRAP2 is known to bind the nuclear localization signal of BRCA1. We cloned mouse BRAP2 cDNA and showed the presence of isoforms.

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