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. 2003 Nov;10(6):1147-8.
doi: 10.1128/cdli.10.6.1147-1148.2003.

Simplified serological diagnosis of endocarditis due to Coxiella burnetii and Bartonella

J M Rolain  1 , C Lecam, D Raoult
Affiliations

Simplified serological diagnosis of endocarditis due to Coxiella burnetii and Bartonella

J M Rolain et al. Clin Diagn Lab Immunol. 2003 Nov.

Abstract

We tested a single-step serological assay against Coxiella burnetii and Bartonella species and found a sensitivity of 100%, and a positive predictive value of 98% for the diagnosis of blood culture-negative endocarditis (BCNE). This assay should be considered as a possible commercial test for the diagnosis of BCNE.

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Figures

FIG. 1.
FIG. 1.
Sensitivity, specificity, positive predictive value, and negative predictive value for the different cutoffs used. The positive group represents patients with endocarditis due to either C. burnetii (n = 30) or Bartonella sp. (n = 20). The negative group comprises 40 apparently healthy blood donors, 99 patients with blood culture-positive endocarditis of known etiology, 15 patients with cat scratch disease, 15 patients with acute Q fever, and 25 patients seropositive for bacterial or viral diseases not related to Bartonella or Coxiella species.
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