doi: 10.1081/NCN-120025239.
A short, efficient synthesis of 2'-deoxypseudoisocytidine based on Heck-chemistry
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- PMID: 14609231
- DOI: 10.1081/NCN-120025239
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A short, efficient synthesis of 2'-deoxypseudoisocytidine based on Heck-chemistry
Nucleosides Nucleotides Nucleic Acids.
2003 Oct.
Abstract
A novel synthesis of 2'-deoxypseudoisocytidine as well as of its phosphoramidite building block for oligonucleotide synthesis is presented. The synthesis is based on Heck-coupling between N-protected pseudoisocytosine and a silyl protected furanoid glycal. With this procedure the corresponding phosphoramidite building block is obtained in 5 steps and an overall yield of 28%.
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