Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2003 Oct;22(10):1919-25.
doi: 10.1081/NCN-120025239.

A short, efficient synthesis of 2'-deoxypseudoisocytidine based on Heck-chemistry

Alain Mayer  1 , Christian J Leumann
Affiliations

A short, efficient synthesis of 2'-deoxypseudoisocytidine based on Heck-chemistry

Alain Mayer et al. Nucleosides Nucleotides Nucleic Acids. 2003 Oct.

Abstract

A novel synthesis of 2'-deoxypseudoisocytidine as well as of its phosphoramidite building block for oligonucleotide synthesis is presented. The synthesis is based on Heck-coupling between N-protected pseudoisocytosine and a silyl protected furanoid glycal. With this procedure the corresponding phosphoramidite building block is obtained in 5 steps and an overall yield of 28%.

PubMed Disclaimer

Publication types

MeSH terms

Substances

LinkOut - more resources