Foreign cells in polymyositis: could stem cell transplantation and pregnancy-derived chimerism lead to the same disease?

Abstract

A growing number of hematopoietic stem cell transplantation centers have reported that patients with chronic graft versus host disease (GVHD) can develop polymyositis (PM). GVHD-PM is similar to idiopathic PM in signs, symptoms, laboratory values, electromyography, radiography, and histology, suggesting that the two conditions may share a similar mechanism in pathogenesis. In chronic GVHD-PM, interactions between allogeneic donor cells and host cells lead to chronic inflammation. In idiopathic PM, the foreign cells could be partially human leukocyte antigen-matched maternal or fetal cells acquired during pregnancy. Thus, PM can be added to the list of potentially allo-autoimmune diseases in which pregnancy-derived microchimerism may play a role.