Review
doi: 10.1083/jcb.200308093.
Myosin V motor proteins: marching stepwise towards a mechanism
Affiliations
- PMID: 14610051
- PMCID: PMC2173644
- DOI: 10.1083/jcb.200308093
Item in Clipboard
Review
Myosin V motor proteins: marching stepwise towards a mechanism
J Cell Biol.
.
Abstract
Mammalian myosin V motors transport cargo processively along actin filaments. Recent biophysical and structural studies have led to a detailed understanding of the mechanism of myosin V, making it perhaps the best understood cytoskeletal motor. In addition to describing the mechanism, this review will illustrate how "dynamic" single molecule measurements can synergize with "static" protein structural studies to produce amazingly clear information on the workings of a nanometer-scale machine.
Figures
A model for the processive motion of mammalian myosin V. See text for details (An emerging consensus mechanism for myosin V). This figure is a modified version of a figure provided by Drs. T. Purcell and J. Spudich.
Similar articles
-
Myosin V walks hand-over-hand: single fluorophore imaging with 1.5-nm localization.Science. 2003 Jun 27;300(5628):2061-5. doi: 10.1126/science.1084398. Epub 2003 Jun 5. Science. 2003. PMID: 12791999
-
Tuning myosin-driven sorting on cellular actin networks.Elife. 2015 Mar 4;4:e05472. doi: 10.7554/eLife.05472. Elife. 2015. PMID: 25738229 Free PMC article.
-
Electrostatic origin of the unidirectionality of walking myosin V motors.Proc Natl Acad Sci U S A. 2013 Oct 22;110(43):17326-31. doi: 10.1073/pnas.1317641110. Epub 2013 Oct 8. Proc Natl Acad Sci U S A. 2013. PMID: 24106304 Free PMC article.
-
The motor mechanism of myosin V: insights for muscle contraction.Philos Trans R Soc Lond B Biol Sci. 2004 Dec 29;359(1452):1829-41. doi: 10.1098/rstb.2004.1576. Philos Trans R Soc Lond B Biol Sci. 2004. PMID: 15647159 Free PMC article. Review.
-
Walking with myosin V.Curr Opin Cell Biol. 2006 Feb;18(1):68-73. doi: 10.1016/j.ceb.2005.12.014. Epub 2005 Dec 27. Curr Opin Cell Biol. 2006. PMID: 16378722 Review.
Cited by
-
A myosin V inhibitor based on privileged chemical scaffolds.Angew Chem Int Ed Engl. 2010 Nov 2;49(45):8484-8. doi: 10.1002/anie.201004026. Angew Chem Int Ed Engl. 2010. PMID: 20878825 Free PMC article. No abstract available.
-
Hypertrophic cardiomyopathy and the myosin mesa: viewing an old disease in a new light.Biophys Rev. 2018 Feb;10(1):27-48. doi: 10.1007/s12551-017-0274-6. Epub 2017 Jul 17. Biophys Rev. 2018. PMID: 28717924 Free PMC article. Review.
-
The cargo-binding domain regulates structure and activity of myosin 5.Nature. 2006 Jul 13;442(7099):212-5. doi: 10.1038/nature04865. Nature. 2006. PMID: 16838021 Free PMC article.
-
Genome-wide comparison and identification of myosin gene family in Arabidopsis thaliana and Helianthus annuus.Heliyon. 2022 Dec 6;8(12):e12070. doi: 10.1016/j.heliyon.2022.e12070. eCollection 2022 Dec. Heliyon. 2022. PMID: 36561675 Free PMC article.
-
The many different cellular functions of MYO7A in the retina.Biochem Soc Trans. 2011 Oct;39(5):1207-10. doi: 10.1042/BST0391207. Biochem Soc Trans. 2011. PMID: 21936790 Free PMC article. Review.
References
-
- Ali, M.Y., S. Uemura, K. Adachi, H. Itoh, K. Kinosita, Jr., and S. Ishiwata. 2002. Myosin V is a left-handed spiral motor on the right-handed actin helix. Nat. Struct. Biol. 9:464–467. - PubMed
-
- Coureux, P.-D., A.L. Wells, J. Menetrey, C.M. Yengo, C.A. Morris, H.L. Sweeeney, and A. Houdusse. 2003. A structural state of the myosin V motor without bound nucleotide. Nature. 425:419–423. - PubMed
-
- Forkey, J.N., M.E. Quinlan, M.A. Shaw, J.E. Corrie, and Y.E. Goldman. 2003. Three-dimensional structural dynamics of myosin V by single-molecule fluorescence polarization. Nature. 422:399–404. - PubMed
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
