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Review
. 2003 Nov 11;61(9 Suppl 5):S24-6.
doi: 10.1212/01.wnl.0000092361.04511.d0.

Measurement of MxA mRNA or protein as a biomarker of IFNbeta bioactivity: detection of antibody-mediated decreased bioactivity (ADB)

Andrew R Pachner  1 , Antonio Bertolotto, Florian Deisenhammer
Affiliations
Review

Measurement of MxA mRNA or protein as a biomarker of IFNbeta bioactivity: detection of antibody-mediated decreased bioactivity (ADB)

Andrew R Pachner et al. Neurology. .

Abstract

Myxovirus A (MxA) is a protein that is specifically induced by treatment with type I cytokines and has proven to be a reliable biomarker of interferon-beta (IFNbeta) bioactivity. IFNbeta-induced MxA can be measured as either protein or mRNA in the blood of IFNbeta-treated patients with MS. In patients with MS who are treated with IFNbeta, loss of the MxA response is caused by high levels of anti-IFNbeta antibodies and is a sensitive marker of lost bioactivity.

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