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Clinical Trial
. 2003 Nov 11;61(9):1279-81.
doi: 10.1212/wnl.61.9.1279.

A randomized trial of botulinum toxin A for treatment of drooling

A Lipp  1 , T Trottenberg, T Schink, A Kupsch, G Arnold
Affiliations
Clinical Trial

A randomized trial of botulinum toxin A for treatment of drooling

A Lipp et al. Neurology. .

Abstract

The authors compared the efficacy of three different doses (18.75, 37.5, and 75 MU per parotid gland) of botulinum toxin A (BTX-A; Dysport, Ipsen Pharma, Germany) injections vs vehicle in patients with sialorrhea (n = 32) using a single-center, prospective, double-blind, placebo-controlled dose-finding study. The primary endpoint was achieved with 75 MU BTX-A without treatment-related adverse events, suggesting BTX-A is a safe and effective treatment for patients with sialorrhea.

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