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. 2003 Nov 19;125(46):13984-7.
doi: 10.1021/ja036390h.

Kinetic evidence for the existence and mechanism of formation of a barrel stave structure from pore-forming dendrimers

Jianbing Zhang  1 , Bingwen Jing, Steven L Regen
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Kinetic evidence for the existence and mechanism of formation of a barrel stave structure from pore-forming dendrimers

Jianbing Zhang et al. J Am Chem Soc. .

Abstract

A dendritic approach to the construction of a homologous series of pore-forming amphiphiles has been developed, based on the use of spermidine, spermine, lysine, and cholic acid. A kinetic analysis of Na+ transport across bilayers of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine by three dendritic amphiphiles has provided the strongest evidence to date for a barrel stave structure.

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