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Review
. 2003;4(11):236.
doi: 10.1186/gb-2003-4-11-236. Epub 2003 Oct 27.

The septins

Makoto Kinoshita  1
Affiliations
Review

The septins

Makoto Kinoshita. Genome Biol. 2003.

Abstract

The septins are guanine-nucleotide binding proteins that mostly form filaments. They are important in cytokinesis and also have roles in sporulation in yeasts and embryonic development and in the nervous system in animals.

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Figures

Figure 1
Figure 1
A phylogenetic tree of the septins in Saccharomyces cerevisiae (Sc), Schizosaccharomyces pombe (Sp), Caenorhabditis elegans (Ce), Drosophila melanogaster (Dm) and humans (Hs). The longest amino-acid sequence among the putative polypeptides generated by each gene was analyzed with the software Phylip [59] using the default mode with the UPGMA method, 1,000 bootstrap replicates and systematic tie-breaking, and Poisson-corrected distances with proportionally distributed gaps. The numbers of predicted coiled coils are shown in parentheses. The scale bar represents 0.1 substitutions.
Figure 2
Figure 2
Multiple alignment of the central regions of representative septins. Amino-acid sequences of the representative septins were aligned using MacVector. Acidic, basic and hydrophobic residues are in purple, blue, and yellow respectively. The GTPase motifs that are conserved in this family - G-1, G-3 and G-4 - are indicated above the sequence. A few other conserved stretches of hydrophobic and charged residues are also recognizable. Species abbreviations are as in Figure 1.
See this image and copyright information in PMC

References

    1. Hartwell LH. Genetic control of the cell division cycle in yeast. IV. Genes controlling bud emergence and cytokinesis. Exp Cell Res. 1971;69:265–276. The original report describing the isolation of the septin mutants. - PubMed
    1. Longtine MS, Demarini DJ, Valencik ML, Al-Awar OS, Fares H, De Virgilio C, Pringle JR. The septins, roles in cytokinesis and other processes. Curr Opin Cell Biol. 1996;8:106–119. doi: 10.1016/S0955-0674(96)80054-8. The first comprehensive review on the septin family, including important previously unpublished observations and insights based on original data. - DOI - PubMed
    1. Cooper JA, Kiehart DP. Septins may form a ubiquitous family of cytoskeletal filaments. J Cell Biol. 1996;134:1345–1348. This article and [4] are reviews of the septin family that focus on their role as components of a novel cytoskeletal system. - PMC - PubMed
    1. Field CM, Kellogg D. Septins, cytoskeletal polymers or signalling GTPases? Trends Cell Biol. 1999;9:387–394. doi: 10.1016/S0962-8924(99)01632-3. See [3]. - DOI - PubMed
    1. Byers B, Goetsch L. A highly ordered ring of membrane-associated filaments in budding yeast. J Cell Biol. 1976;69:717–721. The historical discovery of the electron-dense striations at the mother-bud neck. - PMC - PubMed

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