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. 2003 Sep 1;13(17):2925-8.
doi: 10.1016/s0960-894x(03)00584-5.

Two antiviral compounds from the plant Stylogne cauliflora as inhibitors of HCV NS3 protease

Vinod R Hegde  1 , Haiyan Pu, Mahesh Patel, Pradip R Das, Nancy Butkiewicz, Gladys Arreaza, Vincent P Gullo, Tze-Ming Chan
Affiliations

Two antiviral compounds from the plant Stylogne cauliflora as inhibitors of HCV NS3 protease

Vinod R Hegde et al. Bioorg Med Chem Lett. .

Abstract

The 70% aq methanolic extract of the Peruvian plant Stylogne cauliflora was found to contain two novel oligophenolic compounds SCH 644343 (1) and SCH 644342 (2), which were identified as inhibitors of HCV NS3 protease. The structure of 1 and 2 was established based on high-resolution NMR studies. Compound 1 inhibited HCV NS3 protease with an IC(50) of 0.3 microM, while compound 2 showed an IC(50) of 0.8 microM.

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