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Review
. 2003 Oct 31;479(1-3):93-106.
doi: 10.1016/j.ejphar.2003.08.060.

Dopamine transporter as target for drug development of cocaine dependence medications

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Review

Dopamine transporter as target for drug development of cocaine dependence medications

Aloke K Dutta et al. Eur J Pharmacol. .

Abstract

Because much evidence implicates the dopamine transporter in the reinforcing effects of cocaine, development of potential medications for cocaine dependence has included the dopamine transporter as a target. The present overview covers progress in the drug development area regarding several classes of dopamine uptake inhibitors, with an emphasis on structure-activity relationships that enhance potency and selectivity at transporters for dopamine compared with those for serotonin or norepinephrine. The following categories of compounds are covered: tropane, benztropine, 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine (GBR), methylphenidate, mazindol, and phencyclidine analogs. Activity at transporters as well as on behavior is highlighted.

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