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. 2003 Nov 20;46(24):5121-4.
doi: 10.1021/jm034173l.

Design and synthesis of a potent and selective triazolone-based peroxisome proliferator-activated receptor alpha agonist

Yanping Xu  1 , Daniel Mayhugh, Ashraf Saeed, Xiaodong Wang, Richard C Thompson, Samuel J Dominianni, Raymond F Kauffman, Jaipal Singh, James S Bean, William R Bensch, Robert J Barr, John Osborne, Chahrzad Montrose-Rafizadeh, Richard W Zink, Nathan P Yumibe, Naijia Huang, Debra Luffer-Atlas, Deepa Rungta, Dale E Maise, Nathan B Mantlo
Affiliations

Design and synthesis of a potent and selective triazolone-based peroxisome proliferator-activated receptor alpha agonist

Yanping Xu et al. J Med Chem. .

Abstract

A new series of hPPARalpha agonists containing a 2,4-dihydro-3H-1,2,4-triazol-3-one (triazolone) core is described leading to the discovery of 5 (LY518674), a highly potent and selective PPARalpha agonist.

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