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Review
. 2003 Nov 10:1:88.
doi: 10.1186/1477-7827-1-88.

Angiogenesis in the corpus luteum

Hamish M Fraser  1 , Christine Wulff
Affiliations
Review

Angiogenesis in the corpus luteum

Hamish M Fraser et al. Reprod Biol Endocrinol. .

Abstract

The corpus luteum (CL) is a site of intense angiogenesis. Within a short period, this is followed either by controlled regression of the microvascular tree in the non-fertile cycle, or maintenance and stabilisation of the new vasculature a conceptual cycle. The molecular regulation of these diverse aspects is examined. The CL provides a unique model system in which to study the cellular and molecular regulation of angiogenesis. Vascular endothelial growth factor (VEGF) has been found to have a major role in the CL. By targeting its action at specific stages of the luteal phase in vivo by antagonists, profound inhibitory effects on luteal angiogenesis and function are observed.

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