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. 1992 Dec;17(12):1187-90.
doi: 10.1007/BF00968397.

Enhanced GABA release in cerebral cortical slices derived from rats with thioacetamide-induced hepatic encephalopathy

U Wysmyk  1 , S S Oja, P Saransaari, J Albrecht
Affiliations

Enhanced GABA release in cerebral cortical slices derived from rats with thioacetamide-induced hepatic encephalopathy

U Wysmyk et al. Neurochem Res. 1992 Dec.

Abstract

The release of newly loaded [3H]GABA was studied in slices of different brain regions derived from rats in which acute hepatic encephalopathy (HE) was induced with a hepatotoxin thioacetamide. HE increased both spontaneous and high (50 mM) ammonium chloride-evoked GABA release in cerebral cortical slices by 38% and 50%, respectively. No effects of HE were noted in cerebellar or striatal slices. An increased release of GABA in the cerebral cortex may contribute to the endogenous benzodiazepine-mediated enhancement of GABAergic tone, which is thought to be partly responsible for the pathophysiological mechanism of HE.

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References

    1. Hepatology. 1989 Apr;9(4):594-601 - PubMed
    1. Synapse. 1991 Feb;7(2):141-50 - PubMed
    1. Clin Neuropharmacol. 1988 Oct;11(5):401-22 - PubMed
    1. J Neurochem. 1983 Oct;41(4):1046-51 - PubMed
    1. Neurochem Res. 1987 Mar;12(3):265-9 - PubMed

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