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Review
. 2003 Nov;5(14):1307-15.
doi: 10.1016/j.micinf.2003.09.009.

Oxidative killing of microbes by neutrophils

Dirk Roos  1 , Robin van Bruggen, Christof Meischl
Affiliations
Free article
Review

Oxidative killing of microbes by neutrophils

Dirk Roos et al. Microbes Infect. 2003 Nov.
Free article

Abstract

Neutrophils and other phagocytic leukocytes contain a phagocyte NADPH oxidase enzyme that generates superoxide after cell activation. Reactive oxygen species derived from superoxide, together with proteases liberated from the granules, are used to kill ingested microbes. Dysfunction of the phagocyte NADPH oxidase results in chronic granulomatous disease, with life-threatening infections.

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