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Comment
. 2003 Nov;19(5):634-6.
doi: 10.1016/s1074-7613(03)00304-2.

Amplifying Btk's signal

Pamela L Schwartzberg  1
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Free article
Comment

Amplifying Btk's signal

Pamela L Schwartzberg. Immunity. 2003 Nov.
Free article

Abstract

The Tec kinase Btk is an important regulator of antigen receptor activation of phospholipase C-gamma (PLC-gamma). Data from Carpenter and colleagues (Saito et al., this issue of Immunity) now suggest that Btk also activates phosphatidylinositol-4-phosphate 5-kinase (PIP5K), thereby stimulating a positive feedback loop that generates PI(4,5)P2, the substrate for both phosphoinositide 3-kinase (PI3K) and PLC-gamma.

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