Review
doi: 10.1016/s1074-7613(03)00303-0.
Branches of the B cell antigen receptor pathway are directed by protein conduits Bam32 and Carma1
Affiliations
- PMID: 14614850
- DOI: 10.1016/s1074-7613(03)00303-0
Item in Clipboard
Review
Branches of the B cell antigen receptor pathway are directed by protein conduits Bam32 and Carma1
Immunity.
2003 Nov.
Free article
Abstract
Adaptor proteins act as conduits to channel upstream signals into downstream effector branches. Two B cell-associated adaptors, Bam32 and Carma1, regulate the ERK, JNK, and NF-kappaB branches of the BCR signaling pathway. Recent studies of Bam32-/- and Carma1-/- mice suggest that each adaptor controls a distinct conduit regulating either only proliferation (Bam32) or both the proliferation and survival of B cells (Carma1).
Similar articles
-
Bam32 links the B cell receptor to ERK and JNK and mediates B cell proliferation but not survival.Immunity. 2003 Oct;19(4):621-32. doi: 10.1016/s1074-7613(03)00275-9. Immunity. 2003. PMID: 14563325
-
A novel B lymphocyte-associated adaptor protein, Bam32, regulates antigen receptor signaling downstream of phosphatidylinositol 3-kinase.J Exp Med. 2000 Apr 17;191(8):1319-32. doi: 10.1084/jem.191.8.1319. J Exp Med. 2000. PMID: 10770799 Free PMC article.
-
The B cell SH2/PH domain-containing adaptor Bam32/DAPP1 is required for T cell-independent II antigen responses.Curr Biol. 2003 Oct 28;13(21):1858-66. doi: 10.1016/j.cub.2003.09.034. Curr Biol. 2003. PMID: 14588241
-
Role of the adaptor proteins Bam32, TAPP1 and TAPP2 in lymphocyte activation.Immunol Lett. 2005 Feb 15;97(1):7-17. doi: 10.1016/j.imlet.2004.09.019. Immunol Lett. 2005. PMID: 15626471 Review.
-
NF-kappaB signaling in lymphocytes: a new cast of characters.J Cell Sci. 2004 Jan 1;117(Pt 1):31-9. doi: 10.1242/jcs.00904. J Cell Sci. 2004. PMID: 14657271 Review.
Cited by
-
Regulation of B-cell entry into the cell cycle.Immunol Rev. 2008 Aug;224:183-200. doi: 10.1111/j.1600-065X.2008.00652.x. Immunol Rev. 2008. PMID: 18759927 Free PMC article. Review.
-
Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13.Nat Genet. 2008 Oct;40(10):1156-9. doi: 10.1038/ng.218. Epub 2008 Sep 14. Nat Genet. 2008. PMID: 18794857 Free PMC article.
-
Receptor crosstalk: reprogramming B cell receptor signalling to an alternate pathway results in expression and secretion of the autoimmunity-associated cytokine, osteopontin.J Intern Med. 2009 Jun;265(6):632-43. doi: 10.1111/j.1365-2796.2009.02103.x. J Intern Med. 2009. PMID: 19493057 Free PMC article. Review.
-
TFG is required for autophagy flux and to prevent endoplasmic reticulum stress in CH12 B lymphoma cells.Autophagy. 2021 Sep;17(9):2238-2256. doi: 10.1080/15548627.2020.1821546. Epub 2020 Sep 22. Autophagy. 2021. PMID: 32910713 Free PMC article.
-
B cell antigen receptor signaling and internalization are mutually exclusive events.PLoS Biol. 2006 Jul;4(7):e200. doi: 10.1371/journal.pbio.0040200. PLoS Biol. 2006. PMID: 16719564 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Research Materials
Miscellaneous
