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Review
. 2003 Nov;19(5):637-40.
doi: 10.1016/s1074-7613(03)00303-0.

Branches of the B cell antigen receptor pathway are directed by protein conduits Bam32 and Carma1

Hiroaki Niiro  1 , Edward A Clark
Affiliations
Free article
Review

Branches of the B cell antigen receptor pathway are directed by protein conduits Bam32 and Carma1

Hiroaki Niiro et al. Immunity. 2003 Nov.
Free article

Abstract

Adaptor proteins act as conduits to channel upstream signals into downstream effector branches. Two B cell-associated adaptors, Bam32 and Carma1, regulate the ERK, JNK, and NF-kappaB branches of the BCR signaling pathway. Recent studies of Bam32-/- and Carma1-/- mice suggest that each adaptor controls a distinct conduit regulating either only proliferation (Bam32) or both the proliferation and survival of B cells (Carma1).

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