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Comparative Study
. 1992 Dec;7(12):2555-6.

The amino acid sequence of a mammalian MAP kinase kinase

A Ashworth  1 , S Nakielny, P Cohen, C Marshall
Affiliations
  • PMID: 1461659
Comparative Study

The amino acid sequence of a mammalian MAP kinase kinase

A Ashworth et al. Oncogene. 1992 Dec.

Abstract

The amino acid sequence of the dual specificity mitogen-activated protein kinase kinase (MAPKK) has been determined by cDNA cloning and amino acid sequencing. MAPKK (393 residues, Mr 43,330) is a new member of the protein kinase subclass that comprises byr1 and STE7 that are involved in pheromone dependent signal transduction in yeast, wis1 a mitotic regulator in S. pombe and PBS2, which confers antibiotic resistance in S. cerevisiae.

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