[A comparative study of 3 different types of trivalent measles-mumps-rubella vaccine]

Abstract

The results of a randomized double blind comparative clinical trial are described. 201 children, 101 males and 100 females, average age 3.11 +/- 1.1 (range 15 months to 14 years) received 3 different types of triple vaccine against measles, mumps and rubella. The vaccine containing the strains Edmonston-Zagreb, Rubini and Wistar Ra 27/3 was well tolerated both for the number of side-effects and for the number and the level of the fever attacks, that resulted the most frequent symptom, especially in the children from 2 to 5 years. The differences between side effects were highly significant. In accordance with the obtained results and considering the data of other studies, the Authors conclude that the principal reason of this tolerance is due to more attenuated strain against measles.