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Comparative Study
. 2003 Jul-Aug;65(4):29-36.

[Antigen differences of genetic variants Abent+ and Abent- poliovirus vaccine strain of III type]

[Article in Ukrainian]
V P Shyrobokov  1 , I H Kostenko, I V Nikolaienko
Affiliations
  • PMID: 14618784
Comparative Study

[Antigen differences of genetic variants Abent+ and Abent- poliovirus vaccine strain of III type]

[Article in Ukrainian]
V P Shyrobokov et al. Mikrobiol Z. 2003 Jul-Aug.

Abstract

Hybridomes--producers of monoclonal antibodies (MAB) were obtained able to differentiate the variants Abent+ and Abent- poliovirus vaccine strain in the virus neutralizing reaction. Using the obtained panel the changes of the epitope structure of capsid proteins of poliovirus variants (dissociants) were found which appeared during reproduction in cell culture. It proves the fact that there exist essential antigenic differences of superficial virion's proteins, which appear during the process of dissociation.

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