Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2003;4(3):E46.
doi: 10.1208/pt040346.

Studies on neomycin production using immobilized cells of S marinensis NUV-5 in various reactor configurations: a technical note

Poluri Ellaiah  1 , Bandi Srinivasulu, Kunamneni Adinarayana
Affiliations
Comparative Study

Studies on neomycin production using immobilized cells of S marinensis NUV-5 in various reactor configurations: a technical note

Poluri Ellaiah et al. AAPS PharmSciTech. 2003.

Abstract

Stirred tank, fluidized bed, and airlift reactors produced similar neomycin activity with immobilized cells. Packed bed reactor clearly under performed, probably because of insufficient aeration or mixing. Neomycin production using immobilized cells in fermentors requires good mixing and aeration.

PubMed Disclaimer

References

    1. Berk D, Behie LA, Jones A, Lesser BH, Gaucher M. The production of the antibiotic patulin in a three phase fluidized bed reactor. II. The longevity of the biocatalyst. Can J Chem Eng. 1984;62:120–124.
    1. Sarra M, Casas C, Godia F. Continuous production of a hybrid antibiotic byStreptomyces lividans TK 21 pellets in a three phase fluidized bed reactor. Biotechnol Bioeng. 1997;53:601–610. doi: 10.1002/(SICI)1097-0290(19970320)53:6<601::AID-BIT8>3.0.CO;2-Q. - DOI - PubMed
    1. Morikawa Y, Karube I, Suzuki S. Continuous production of bacitracin by immobilized living whole cells ofBacillus sp. Biotechnol Bioeng. 1980;22:1015–1023. doi: 10.1002/bit.260220510. - DOI
    1. Berk D, Behie LA, Jones A, Lesser BH, Gaucher M. The production of the antibiotic patulin in a three phase fluidized bed reactor. I. Effects of media composition. Can J Chem Eng. 1984;62:112–119.
    1. Deo YM, Costerton JW, Gaucher RM. Semicontinuous and continuous production of antibiotics by immobilized fungal cells. Developments in Industrial microbiology. Appl Microbiol Biotechnol. 1985;21:220–225. doi: 10.1007/BF00295126. - DOI

Publication types

MeSH terms

LinkOut - more resources