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. 2004 Jan;167(1):38-44.
doi: 10.1016/s1090-0233(03)00055-8.

Changes in some acute phase protein and immunoglobulin concentrations in cats affected by feline infectious peritonitis or exposed to feline coronavirus infection

A Giordano  1 , V Spagnolo, A Colombo, S Paltrinieri
Affiliations

Changes in some acute phase protein and immunoglobulin concentrations in cats affected by feline infectious peritonitis or exposed to feline coronavirus infection

A Giordano et al. Vet J. 2004 Jan.

Abstract

The possible role of some acute phase proteins (APPs) and immunoglobulins in both the pathogenesis and diagnosis of feline infectious peritonitis (FIP) has been investigated. Serum protein electrophoresis and the concentration of haptoglobin (Hp), serum amyloid A (SAA), alpha(1)-acid glycoprotein (AGP), IgG and IgM were evaluated in cats exposed to feline coronavirus (FCoV) and in cats with FIP. The highest concentration of APPs was detected in affected cats, confirming the role of these proteins in supporting a clinical diagnosis of FIP. Repeated samplings from both FIP affected and FCoV-exposed cats showed that when FIP appeared in the group, all the cats had increased APP levels. This increase persisted only in cats that developed FIP (in spite of a decrease in alpha(2)-globulins) but it was only transient in FCoV-exposed cats, in which a long lasting increase in alpha(2)-globulins was observed. These results suggest that changes in the electrophoretic motility of APPs or APPs other than Hp, SAA and AGP might be involved in the pathogenesis of FIP or in protecting cats from the disease.

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Figures

Fig. 1
Fig. 1
Serum amyloid A concentrations (μg/mL) in the four samples from FCoV-exposed cats.
Fig. 2
Fig. 2
Haptoglobin concentrations (mg/mL) in the four samples from FCoV-exposed cats.
Fig. 3
Fig. 3
α1-Acid glycoprotein concentrations (mg/mL) in the four samples FCoV-exposed cats.
See this image and copyright information in PMC

Comment in

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