Comparative Study
doi: 10.1016/j.jmb.2003.09.037.
Single-cell analysis of lambda immunity regulation
Affiliations
- PMID: 14623180
- DOI: 10.1016/j.jmb.2003.09.037
Item in Clipboard
Comparative Study
Single-cell analysis of lambda immunity regulation
J Mol Biol.
.
Abstract
We have examined expression of the lambdacI operon in single cells via a rex Colon, two colons gfp substitution. Although average fluorescence agreed with expectations for expression of lambda-repressor, fluorescence fluctuated greatly from cell-to-cell. Fluctuations in repressor concentration are not predicted by previous models and are tolerated in part by a regulatory response to DNA damage.
Similar articles
-
[Attenuation of bacteriophage phi80 repression].Genetika. 1996 Sep;32(9):1172-5. Genetika. 1996. PMID: 9026457 Russian.
-
Polarity within pM and pE promoted phage lambda cI-rexA-rexB transcription and its suppression.Can J Microbiol. 2005 Jan;51(1):37-49. doi: 10.1139/w04-115. Can J Microbiol. 2005. PMID: 15782233
-
Regulation of bacteriophage lambda int gene expression.J Mol Biol. 1982 Jul 5;158(3):327-46. doi: 10.1016/0022-2836(82)90201-7. J Mol Biol. 1982. PMID: 6215498 No abstract available.
-
How the lambda repressor and cro work.Cell. 1980 Jan;19(1):1-11. doi: 10.1016/0092-8674(80)90383-9. Cell. 1980. PMID: 6444544 Review. No abstract available.
-
Switches in bacteriophage lambda development.Annu Rev Genet. 2005;39:409-29. doi: 10.1146/annurev.genet.39.073003.113656. Annu Rev Genet. 2005. PMID: 16285866 Review.
Cited by
-
Protection of bacteriophage-sensitive Escherichia coli by lysogens.Proc Natl Acad Sci U S A. 2022 Apr 5;119(14):e2106005119. doi: 10.1073/pnas.2106005119. Epub 2022 Mar 28. Proc Natl Acad Sci U S A. 2022. PMID: 35344423 Free PMC article.
-
Biological Properties of 12 Newly Isolated Acinetobacter baumannii-Specific Bacteriophages.Viruses. 2023 Jan 13;15(1):231. doi: 10.3390/v15010231. Viruses. 2023. PMID: 36680270 Free PMC article.
-
The lysis-lysogeny decision of bacteriophage 933W: a 933W repressor-mediated long-distance loop has no role in regulating 933W P(RM) activity.J Bacteriol. 2011 Jul;193(13):3313-23. doi: 10.1128/JB.00119-11. Epub 2011 May 6. J Bacteriol. 2011. PMID: 21551291 Free PMC article.
-
Tethered particle analysis of supercoiled circular DNA using peptide nucleic acid handles.Nat Protoc. 2014 Sep;9(9):2206-23. doi: 10.1038/nprot.2014.152. Epub 2014 Aug 21. Nat Protoc. 2014. PMID: 25144271
-
The bacteriophage lambda CI protein finds an asymmetric solution.Curr Opin Struct Biol. 2009 Feb;19(1):79-86. doi: 10.1016/j.sbi.2008.12.008. Epub 2009 Jan 30. Curr Opin Struct Biol. 2009. PMID: 19181516 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
