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Comparative Study
. 2003 Nov 28;334(3):363-72.
doi: 10.1016/j.jmb.2003.09.037.

Single-cell analysis of lambda immunity regulation

Kristoffer Baek  1 , Sine Svenningsen, Harvey Eisen, Kim Sneppen, Stanley Brown
Affiliations
Comparative Study

Single-cell analysis of lambda immunity regulation

Kristoffer Baek et al. J Mol Biol. .

Abstract

We have examined expression of the lambdacI operon in single cells via a rex Colon, two colons gfp substitution. Although average fluorescence agreed with expectations for expression of lambda-repressor, fluorescence fluctuated greatly from cell-to-cell. Fluctuations in repressor concentration are not predicted by previous models and are tolerated in part by a regulatory response to DNA damage.

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