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Comment
. 2003 Nov 25;100(24):13737-8.
doi: 10.1073/pnas.2536856100. Epub 2003 Nov 17.

A role for extracellular matrix binding receptors in regulating hematopoietic growth factor signaling

Richard B Gaynor  1
Affiliations
Comment

A role for extracellular matrix binding receptors in regulating hematopoietic growth factor signaling

Richard B Gaynor. Proc Natl Acad Sci U S A. .
No abstract available

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Fig. 1.
Fig. 1.
Proposed mechanism of GM-CSF receptor signal modulation by the laminin receptor (LR). Circulating granulocytes and monocytes are not activated by low levels of GM-CSF due to the binding of the LR to the GM-CSF receptor α (αR) and β (βR) subunits. On transendothelial migration, these cells attach to the basement membrane via interactions of the LR and the integrin receptor (IR) with extracellular matrix (ECM) proteins such as laminin, fibronectin, and collagen. This process relieves the inhibitory effects of the LR on GM-CSF signaling and increases the proliferation, survival, and maturation of myeloid cells and augments their host defense function.
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