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. 2003 Nov 26;125(47):14222-3.
doi: 10.1021/ja037559u.

High-sensitivity observation of dipolar exchange and NOEs between exchangeable protons in proteins by 3D solid-state NMR spectroscopy

Eric K Paulson  1 , Corey R Morcombe, Vadim Gaponenko, Barbara Dancheck, R Andrew Byrd, Kurt W Zilm
Affiliations

High-sensitivity observation of dipolar exchange and NOEs between exchangeable protons in proteins by 3D solid-state NMR spectroscopy

Eric K Paulson et al. J Am Chem Soc. .

Abstract

A highly sensitive new 1H-detected 3D solid-state NMR method is described for characterizing 1H-1H spin exchange in nanocrystalline samples of 15N- and 2H-enriched protein. Long-range contacts are observed in human ubiquitin. The method is also used to show that numerous NOEs between backbone amides and crystal water protons can be observed.

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