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. 2003 Dec;9(12):1469-76.
doi: 10.1038/nm962. Epub 2003 Nov 16.

Hsp70 promotes antigen-presenting cell function and converts T-cell tolerance to autoimmunity in vivo

Douglas G Millar  1 , Kristine M Garza, Bernhard Odermatt, Alisha R Elford, Nobuyuki Ono, Zihai Li, Pamela S Ohashi
Affiliations

Hsp70 promotes antigen-presenting cell function and converts T-cell tolerance to autoimmunity in vivo

Douglas G Millar et al. Nat Med. 2003 Dec.

Abstract

Pathogens or pathogen-associated molecular patterns can signal to cells of the innate immune system and trigger effective adaptive immunity. However, relatively little is known about how the innate immune system detects tissue injury or necrosis. Evidence suggests that the release of heat-shock proteins (HSPs) may provide adjuvant-like signals, but the ability of HSPs to promote activation or tolerance in vivo has not been addressed. In this study we show that Hsp70 promotes dendritic cell (DC) function and, together with antigen, triggers autoimmune disease in vivo.

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Comment in

  • Autoimmunity heats up.
    Gelman AE, Turka LA. Gelman AE, et al. Nat Med. 2003 Dec;9(12):1465-6. doi: 10.1038/nm1203-1465. Nat Med. 2003. PMID: 14647523 No abstract available.

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