Modelling of in vivo calcium metabolism. I. Optimal cooperation between constant and rhythmic behaviours
- PMID: 1462741
- DOI: 10.1007/BF00168138
Modelling of in vivo calcium metabolism. I. Optimal cooperation between constant and rhythmic behaviours
Abstract
The relevance of nonlinear dynamics to calcium metabolism led us to reevaluate the role of Ca-regulating hormones in Ca homeostasis. We suggest that, firstly, the main Ca metabolic functions in rat-bone and gut--are organized as dynamic entities able to generate various temporal expressions, including self-oscillating patterns and, secondly, Ca homeostasis results from interaction between both metabolic and hormonal oscillators. Following this schema, a major role for the hormonal system, with its circadian pattern, could be to act directly on metabolic functions or indirectly through feeding behaviour, in order to optimize, coordinate and synchronize the Ca fluxes at ECF level.
Similar articles
-
A physiological view of in vivo calcium dynamics: the regulation of a nonlinear self-organized system.Bone. 1989;10(2):77-86. doi: 10.1016/8756-3282(89)90002-1. Bone. 1989. PMID: 2765313
-
Modelling of in vivo calcium metabolism. II. Minimal structure or maximum dynamic diversity: the interplay of biological constraints.Acta Biotheor. 1992 Sep;40(2-3):103-11. doi: 10.1007/BF00168139. Acta Biotheor. 1992. PMID: 1462728
-
Calcium metabolism in the rat: a temporal self-organized model.Am J Physiol. 1988 Jan;254(1 Pt 2):R134-49. doi: 10.1152/ajpregu.1988.254.1.R134. Am J Physiol. 1988. PMID: 3337267
-
Role of the calcium-sensing receptor in extracellular calcium homeostasis.Best Pract Res Clin Endocrinol Metab. 2013 Jun;27(3):333-43. doi: 10.1016/j.beem.2013.02.006. Epub 2013 Mar 13. Best Pract Res Clin Endocrinol Metab. 2013. PMID: 23856263 Review.
-
Contribution of intestine, bone, kidney, and dialysis to extracellular fluid calcium content.Clin J Am Soc Nephrol. 2010 Jan;5 Suppl 1:S12-22. doi: 10.2215/CJN.05970809. Clin J Am Soc Nephrol. 2010. PMID: 20089498 Review.