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. 1992:38 ( Pt 2):43-9.

Involvement of bradykinin-induced [Ca2+]i oscillations in phosphatidylcholine breakdown in K-ras-transformed fibroblasts

T Fu  1 , Y Okano, Y Nozawa
Affiliations
  • PMID: 1462844

Involvement of bradykinin-induced [Ca2+]i oscillations in phosphatidylcholine breakdown in K-ras-transformed fibroblasts

T Fu et al. Agents Actions Suppl. 1992.

Abstract

Bradykinin (BK) induced a biphasic 1,2-diacylglycerol production in both K-ras-transformed (DT) cells and its parent NIH3T3 cells. The first phase was coincident with the transient phosphoinositide turnover and the second sustained phase was derived from hydrolysis of phosphatidylcholine (PC). In DT cells, the PC breakdown was considerably due to phospholipase C and dependent on intracellular calcium oscillations.

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