Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2004 Feb 15;378(Pt 1):213-7.
doi: 10.1042/BJ20031193.

Mitochondrial cytochrome c release may occur by volume-dependent mechanisms not involving permeability transition

Vladimir Gogvadze  1 , John D Robertson, Mari Enoksson, Boris Zhivotovsky, Sten Orrenius
Affiliations

Mitochondrial cytochrome c release may occur by volume-dependent mechanisms not involving permeability transition

Vladimir Gogvadze et al. Biochem J. .

Abstract

The mechanisms regulating mitochondrial outer-membrane permeabilization and the release of cytochrome c during apoptosis remain controversial. In the present study, we show in an in vitro model system that the release of cytochrome c may occur via moderate modulation of mitochondrial volume, irrespective of the mechanism leading to the mitochondrial swelling. In contrast with mitochondrial permeability transition-dependent release of cytochrome c, in the present study mitochondria remain intact and functionally active.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. J Biol Chem. 2001 Jun 1;276(22):19066-71 - PubMed
    1. Biochem J. 1990 May 15;268(1):147-52 - PubMed
    1. J Exp Med. 1996 Sep 1;184(3):1155-60 - PubMed
    1. Adv Enzyme Regul. 1999;39:157-71 - PubMed
    1. J Biol Chem. 1993 Jan 15;268(2):997-1004 - PubMed

Publication types