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. 2004 Feb 15;378(Pt 1):213-7.
doi: 10.1042/BJ20031193.

Mitochondrial cytochrome c release may occur by volume-dependent mechanisms not involving permeability transition

Vladimir Gogvadze  1 , John D Robertson, Mari Enoksson, Boris Zhivotovsky, Sten Orrenius
Affiliations

Mitochondrial cytochrome c release may occur by volume-dependent mechanisms not involving permeability transition

Vladimir Gogvadze et al. Biochem J. .

Abstract

The mechanisms regulating mitochondrial outer-membrane permeabilization and the release of cytochrome c during apoptosis remain controversial. In the present study, we show in an in vitro model system that the release of cytochrome c may occur via moderate modulation of mitochondrial volume, irrespective of the mechanism leading to the mitochondrial swelling. In contrast with mitochondrial permeability transition-dependent release of cytochrome c, in the present study mitochondria remain intact and functionally active.

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