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Comparative Study
. 2003 Dec;58(12):1263-70.
doi: 10.1016/j.farmac.2003.07.009.

Antiparasitic activity of highly conjugated pyrimidine-2,4-dione derivatives

Nadine Azas  1 , Pascal Rathelot, Serge Djekou, Florence Delmas, A Gellis, Carole Di Giorgio, Patrice Vanelle, Pierre Timon-David
Affiliations
Comparative Study

Antiparasitic activity of highly conjugated pyrimidine-2,4-dione derivatives

Nadine Azas et al. Farmaco. 2003 Dec.

Abstract

4-[2-(1,3-Dimethyl-5-nitro-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)vinyl]benzaldehyde was synthesized in four steps from 6-methyl-1H,3H-pyrimidine-2,4-dione. This aldehyde was functionalized by various substituted anilines or substituted benzylamines. Antiparasitic activities of the corresponding azomethines were assessed against Plasmodium falciparum, Trichomonas vaginalis and Leishmania infantum compared to their toxicity versus human cells.

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