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Review
. 2003 Nov;4(11):911-6.
doi: 10.1038/nrg1206.

The nature and identification of quantitative trait loci: a community's view

Oduola Abiola, Joe M Angel, Philip Avner, Alexander A Bachmanov, John K Belknap, Beth Bennett, Elizabeth P Blankenhorn, David A Blizard, Valerie Bolivar, Gundrun A Brockmann, Kari J Buck, Jean-Francoise Bureau, William L Casley, Elissa J Chesler, James M Cheverud, Gary A Churchill, Melloni Cook, John C Crabbe, Wim E Crusio, Ariel Darvasi, Gerald de Haan, Peter Dermant, R W Doerge, Rosemary W Elliot, Charles R Farber, Lorraine Flaherty, Jonathan Flint, Howard Gershenfeld, John P Gibson, Jing Gu, Weikuan Gu, Heinz Himmelbauer, Robert Hitzemann, Hui-Chen Hsu, Kent Hunter, Fuad F Iraqi, Ritsert C Jansen, Thomas E Johnson, Byron C Jones, Gerd Kempermann, Frank Lammert, Lu Lu, Kenneth F Manly, Douglas B Matthews, Juan F Medrano, Margarete Mehrabian, Guy Mittlemann, Beverly A Mock, Jeffrey S Mogil, Xavier Montagutelli, Grant Morahan, John D Mountz, Hiroki Nagase, Richard S Nowakowski, Bruce F O'Hara, Alexander V Osadchuk, Beverly Paigen, Abraham A Palmer, Jeremy L Peirce, Daniel Pomp, Michael Rosemann, Glenn D Rosen, Leonard C Schalkwyk, Ze'ev Seltzer, Stephen Settle, Kazuhiro Shimomura, Siming Shou, James M Sikela, Linda D Siracusa, Jimmy L Spearow, Cory Teuscher, David W Threadgill, Linda A Toth, Ayo A Toye, Csaba Vadasz, Gary Van Zant, Edward Wakeland, Robert W Williams, Huang-Ge Zhang, Fei Zou; Complex Trait Consortium
Review

The nature and identification of quantitative trait loci: a community's view

Oduola Abiola et al. Nat Rev Genet. 2003 Nov.

Abstract

This white paper by eighty members of the Complex Trait Consortium presents a community's view on the approaches and statistical analyses that are needed for the identification of genetic loci that determine quantitative traits. Quantitative trait loci (QTLs) can be identified in several ways, but is there a definitive test of whether a candidate locus actually corresponds to a specific QTL?

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