doi: 10.1016/0167-5699(92)90027-5.
Cervical lymphatics, the blood-brain barrier and the immunoreactivity of the brain: a new view
Affiliations
- PMID: 1463583
- DOI: 10.1016/0167-5699(92)90027-5
Item in Clipboard
Cervical lymphatics, the blood-brain barrier and the immunoreactivity of the brain: a new view
Immunol Today.
1992 Dec.
Abstract
This new view of the immunoreactivity of the normal brain is based on three key components. First, there is an active and highly-regulated communication between the brain and the central immune organs. Secondly, the connection from the brain to the draining nodes is much larger than previously appreciated. And third, the blood-brain barrier, by virtue of its selective permeability properties, contributes to the regulation of immunoregulatory cells and molecules in the brain cell microenvironment.
Similar articles
-
Physiology and immunology of lymphatic drainage of interstitial and cerebrospinal fluid from the brain.Neuropathol Appl Neurobiol. 1995 Jun;21(3):175-80. doi: 10.1111/j.1365-2990.1995.tb01047.x. Neuropathol Appl Neurobiol. 1995. PMID: 7477724 Review. No abstract available.
-
Antigen-dependent intrathecal antibody synthesis in the normal rat brain: tissue entry and local retention of antigen-specific B cells.J Immunol. 1998 Jul 15;161(2):692-701. J Immunol. 1998. PMID: 9670944
-
Drainage of brain extracellular fluid into blood and deep cervical lymph and its immunological significance.Brain Pathol. 1992 Oct;2(4):269-76. doi: 10.1111/j.1750-3639.1992.tb00703.x. Brain Pathol. 1992. PMID: 1341962 Review.
-
Immune surveillance of the human central nervous system (CNS): different migration pathways of immune cells through the blood-brain barrier and blood-cerebrospinal fluid barrier in healthy persons.Cytometry A. 2006 Mar;69(3):147-51. doi: 10.1002/cyto.a.20225. Cytometry A. 2006. PMID: 16479603 Review.
-
Afferent and efferent immunological pathways of the brain. Anatomy, function and failure.Brain Behav Immun. 2014 Feb;36:9-14. doi: 10.1016/j.bbi.2013.10.012. Epub 2013 Oct 18. Brain Behav Immun. 2014. PMID: 24145049 Review.
Cited by
-
Exploiting Radiation Therapy to Restore Immune Reactivity of Glioblastoma.Front Oncol. 2021 May 20;11:671044. doi: 10.3389/fonc.2021.671044. eCollection 2021. Front Oncol. 2021. PMID: 34094969 Free PMC article. Review.
-
Embracing rejection: Immunologic trends in brain metastasis.Oncoimmunology. 2016 Apr 11;5(7):e1172153. doi: 10.1080/2162402X.2016.1172153. eCollection 2016 Jul. Oncoimmunology. 2016. PMID: 27622023 Free PMC article. Review.
-
Clinical Applications of Immunotherapy for Recurrent Glioblastoma in Adults.Cancers (Basel). 2023 Jul 31;15(15):3901. doi: 10.3390/cancers15153901. Cancers (Basel). 2023. PMID: 37568717 Free PMC article. Review.
-
Pediatric glioblastoma: mechanisms of immune evasion and potential therapeutic opportunities.Cancer Immunol Immunother. 2022 Aug;71(8):1813-1822. doi: 10.1007/s00262-021-03131-y. Epub 2022 Jan 12. Cancer Immunol Immunother. 2022. PMID: 35020009 Free PMC article. Review.
-
Whole-body PET Imaging of T-cell Response to Glioblastoma.Clin Cancer Res. 2021 Dec 1;27(23):6445-6456. doi: 10.1158/1078-0432.CCR-21-1412. Epub 2021 Sep 21. Clin Cancer Res. 2021. PMID: 34548318 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
