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Review
. 2003 Nov;12(5):1067-75.
doi: 10.1016/s1097-2765(03)00441-6.

Enigmatic variations: divergent modes of regulating eukaryotic DNA replication

Stephen E Kearsey  1 , Sue Cotterill
Affiliations
Free article
Review

Enigmatic variations: divergent modes of regulating eukaryotic DNA replication

Stephen E Kearsey et al. Mol Cell. 2003 Nov.
Free article

Abstract

Proteins involved in DNA replication are conserved from yeast to mammals, suggesting that the mechanism was established at an early stage of eukaryotic evolution. In spite of this common origin, recent findings have revealed surprising variations in how replication initiation is controlled, implying that a conserved mechanism has not necessarily resulted in regulatory conservation.

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