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Clinical Trial
. 2003 Dec;47(12):3964-6.
doi: 10.1128/AAC.47.12.3964-3966.2003.

Linezolid penetration into bone and joint tissues infected with methicillin-resistant staphylococci

Friedrich Kutscha-Lissberg  1 , Ute Hebler, Gert Muhr, Manfred Köller
Affiliations
Clinical Trial

Linezolid penetration into bone and joint tissues infected with methicillin-resistant staphylococci

Friedrich Kutscha-Lissberg et al. Antimicrob Agents Chemother. 2003 Dec.

Abstract

Penetration of linezolid into bone and joint tissues was studied by high-performance liquid chromatography in 13 patients suffering from implant-associated infections with methicillin-resistant staphylococci. Mean concentrations of linezolid in infected tissues were greater than 10 mg/liter in a sampling time range of 35 to 124 min after administration of the preoperative dose, except in bone specimens, where they reached 3.9 +/- 2.0 mg/liter.

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