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. 2003 Dec;47(12):3976-8.
doi: 10.1128/AAC.47.12.3976-3978.2003.

Efficacy of voriconazole in treatment of systemic scedosporiosis in neutropenic mice

Javier Capilla  1 , Carolina Serena, F Javier Pastor, Montserrat Ortoneda, Josep Guarro
Affiliations

Efficacy of voriconazole in treatment of systemic scedosporiosis in neutropenic mice

Javier Capilla et al. Antimicrob Agents Chemother. 2003 Dec.

Abstract

We have evaluated the efficacy of voriconazole (VRC) in a murine model of systemic infection by Scedosporium apiospermum. The survival of mice treated with VRC at 5, 20, or 40 mg/kg/day was greater than that of the control group (P< or =0.0009). VRC reduced the tissue burden in the spleen and brain (P<0.001 in both organs) in comparison with that of the control group.

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Figures

FIG. 1.
FIG. 1.
Survival curves of male immunodepressed OF-1 mice infected i.v. with S. apiospermum and left untreated, given PEG 200, or treated with AMB at a dose of 0.8 mg/kg i.v. or 1.5 mg/kg i.p. or with VRC at 5, 20, or 40 mg/kg p.o. Treatments were started on day 1 postinfection and continued for 10 days.
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