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Review
. 2003 Dec;4(12):1169-76.
doi: 10.1038/ni1012.

Suppressors of cytokine signaling and immunity

Masato Kubo  1 , Toshikatsu Hanada, Akihiko Yoshimura
Affiliations
Review

Suppressors of cytokine signaling and immunity

Masato Kubo et al. Nat Immunol. 2003 Dec.

Abstract

The suppressors of cytokine signaling (SOCS) and cytokine-inducible SH2 protein are key physiological regulators of the immune system. Principally, SOCS1 and SOCS3 regulate T cells as well as antigen-presenting cells, including macrophages and dendritic cells. Here we review the function of SOCS1 and SOCS3 in innate and adaptive immunity, with particular emphasis on the relationship between immune regulation and SOCS.

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