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. 2003 Nov;66(11):1515-6.
doi: 10.1021/np0303106.

Cytotoxic cucurbitacin constituents from Sloanea zuliaensis

Nelson Rodriguez  1 , Yelkaira Vasquez, Ahmed A Hussein, Phyllis D Coley, Pablo N Solis, Mahabir P Gupta
Affiliations

Cytotoxic cucurbitacin constituents from Sloanea zuliaensis

Nelson Rodriguez et al. J Nat Prod. 2003 Nov.

Abstract

A new cucurbitacin D analogue, 2-deoxycucurbitacin D (1), as well as cucurbitacin D (2) and 25-acetylcucurbitacin F (3) were isolated from Sloanea zuliaensis. Compound 1 was found only in the young leaves of the plant and not in the mature leaves, and its structure was established using spectroscopic means. Compounds 1-3 demonstrated potent cytotoxic activity against breast (MCF-7), lung (H-460), and central nervous system (SF-268) human cancer cell lines.

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