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. 2003 Dec;31(Pt 6):1526-9.
doi: 10.1042/bst0311526.

Modelling the controls of the eukaryotic cell cycle

B Novák  1 , J J Tyson
Affiliations

Modelling the controls of the eukaryotic cell cycle

B Novák et al. Biochem Soc Trans. 2003 Dec.

Abstract

The eukaryotic cell-division cycle is regulated by three modules that control G(1)/S, G(2)/M and meta/anaphase transitions. By using mathematical modelling, we show the dynamic characteristics of these individual modules and we also assemble them together into a comprehensive model of the eukaryotic cell-division cycle. With this comprehensive model, we also discuss the mechanisms by which different checkpoint pathways stabilize different cell-cycle states and inhibit the transitions that drive cell-cycle progression.

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