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Case Reports
. 2003 Oct;56(2-3):205-8.
doi: 10.1016/j.eplepsyres.2003.09.006.

No evidence for a seriously increased malignancy risk in LGI1-caused epilepsy

Eylert Brodtkorb  1 , Karl O Nakken, Ortrud K Steinlein
Affiliations
Case Reports

No evidence for a seriously increased malignancy risk in LGI1-caused epilepsy

Eylert Brodtkorb et al. Epilepsy Res. 2003 Oct.

Abstract

The Leucine-rich Glioma Inactivated-1 (LGI1) gene is supposed to be a tumor suppressor gene involved in glial tumors. Mutations in this gene were recently found to cause autosomal dominant lateral temporal lobe epilepsy (ADLTE). We have now analysed the comorbidity in a large Norwegian ADLTE family. No evidence was found that LGI1 is a high-penetrance tumor suppressor gene associated with a serious risk for malignancies in ADLTE families.

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