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. 2003 Dec 15;13(24):4371-4.
doi: 10.1016/j.bmcl.2003.09.033.

Synthesis and antiviral evaluation of 3-hydroxy-2-methylpyridin-4-one dideoxynucleoside derivatives

Karine Barral  1 , Robert C Hider, Jan Balzarini, Johan Neyts, Erik De Clercq, Michel Camplo
Affiliations

Synthesis and antiviral evaluation of 3-hydroxy-2-methylpyridin-4-one dideoxynucleoside derivatives

Karine Barral et al. Bioorg Med Chem Lett. .

Abstract

We describe the synthesis and the antiviral evaluation of novel alpha and beta dideoxynucleoside derivatives in which the base has been replaced by a 3-hydroxy-2-methylpyridin-4-one. The syntheses were successfully achieved by the use of the standard Vorbrüggen coupling conditions. Moderate activity of these compounds were found on herpes simplex virus (HSV) type 1 and type 2.

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