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. 2003 Dec 15;13(24):4477-80.
doi: 10.1016/j.bmcl.2003.08.079.

Duloxetine (Cymbalta), a dual inhibitor of serotonin and norepinephrine reuptake

F P Bymaster  1 , E E Beedle, J Findlay, P T Gallagher, J H Krushinski, S Mitchell, D W Robertson, D C Thompson, L Wallace, D T Wong
Affiliations

Duloxetine (Cymbalta), a dual inhibitor of serotonin and norepinephrine reuptake

F P Bymaster et al. Bioorg Med Chem Lett. .

Abstract

A series of naphthalenyloxy-arylpropylamines have been prepared and are demonstrated to be inhibitors of both serotonin and norepinephrine reuptake. One member of this series, duloxetine (Cymbalta) has proven to be effective in clinical trials for the treatment of depression.

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