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. 2003 Dec 15;13(24):4481-3.
doi: 10.1016/j.bmcl.2003.08.081.

Conicamin, a novel histamine antagonist from the mediterranean tunicate Aplidium conicum

Anna Aiello  1 , Francesca Borrelli, Raffaele Capasso, Ernesto Fattorusso, Paolo Luciano, Marialuisa Menna
Affiliations

Conicamin, a novel histamine antagonist from the mediterranean tunicate Aplidium conicum

Anna Aiello et al. Bioorg Med Chem Lett. .

Abstract

In addition to the known 6-bromo-hypaphorine (2) and plakohypaphorine-A (3), the methanol extract of the Mediterranean tunicate Aplidium conicum was shown to contain conicamin, a novel indole alkaloid having histamine-antagonistic activity which structure was determined to be 1 on the basis of the spectral data.

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